RESEARCH PAPERS
Anti-cancerous and anti-tumor research papers
Tumor cell growth inhibition by several Annonaceous acetogenins in an in vitro disk diffusion assay
This study shows that annonaceous acetogenins present in soursop stops cell growth for cancerous cells and it is also equally effective on drug resistant cancer cells.
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Selective growth inhibition of human breast cancer cells by graviola fruit extract in vitro and in vivo involving downregulation of EGFR expression
This study shows the effect of soursop fruit extract on human breast cancer cells and it shows that the growth of the cells is inhibited.
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The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells
This study shows that bullatacin, an acetogenin of soursop, reduces cellular energy and is toxic to multidrug-resistant cancer cells.
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Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism
Pancreatic tumors become resistant to conventional chemotherapies. This study shows that graviola or soursop extract killed pancreatic cancer cells by blocking their access to the energy source ATP.
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Annonacin induces cell cycle-dependent growth arrest and apoptosis in estrogen receptor- _-related pathways in MCF-7 cells
Breast cancer cells commonly become resistant to Tamoxifen. This study shows that annonacin (which in present in soursop) stopped cancer cells’ growth and reduced tumor size at 7-22 days.
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Chemopreventive Potential of Annona Muricata L Leaves on Chemically-Induced Skin Papillomagenesis in Mice
This study shows that the extract of soursop leaves was able to suppress tumor before it started growing as well as growth of the tumor even at lower dosage.
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Selective Action of Acetogenin Mitochondrial Complex I Inhibitors
This is a study on the acetogenins from various plants. Acetogenin from soursop proved to be toxic to selective bad cells and a panel of tumor cell lines including multidrug-resistant cells.
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Quantitative Assessment of the Relative Antineoplastic Potential of the n-butanolic Leaf Extract of Annona Muricata Linn. in Normal and Immortalized Human Cell Lines
Quantitative Assessment of the Relative Antineoplastic Potential of the n-butanolic Leaf Extract of Annona Muricata Linn. in Normal and Immortalized Human Cell Lines
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Anti-depression properties
Isoquinoline derivatives isolated from the fruit of Annona muricata as 5-HTergic 5-HT1A receptor agonists in rats: unexploited antidepressive (lead) products
This study shows the effect of isoquinoline, a compound present in the fruit soursop on rats and it shows an antidrepressive effect.
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For herpes simplex virus
Effect of the extract of Annona muricata and Petunia nyctaginiflora on Herpes simplex virus
This study shows the effect o extract of Annona muricata on Herpes Simplex virus.
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Anti-diabetic properties
Anti Hyperglycemic Activities of Annona Muricata (Linn)
This study shows that leaf extracts of soursop have anti-diabetic properties as it helps in reducing blood glucose level.
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Hypotensive properties
Possible mechanisms of action of the hypotensive effect of Annona muricata (soursop) in normotensive Sprague–Dawley rats
This study shows that leaves of the soursop caused significant reduction in blood pressure with only a slight affect on heart rates.
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Anti-inflammatory properties
Antinociceptive and Anti-inflammatory activities of the ethanol extract of Annona Muricata L. leaves in Animal Models
This study shows that sourop leaves have tremendous pain-relieving and anti-inflammatory or anti-swelling properties.
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*Analyses made at the Laboratorio FIM de Nutricion, Havana, Cuba.